The building once housed the original St. Francis Hospital, the city’s first hospital established in 1887.
Officials said the building has been on the market for years but received no serious offers. So, the center is being closed to save money.
The building also houses two other major medical offices, Pikes Peak Hospice and Palliative Care and Select Long Term Acute Care.
Pikes Peak Hospice and Palliative Care recently signed a three-year lease and will remain in the building.
Select Long Term Acute Care will move to the sixth floor of St. Francis Medical Center near Powers Boulevard and Woodmen Road.
“Efforts have been made to preserve services at St. Francis Health Center for more than 15 years, but it’s now proving to be cost-prohibitive and affecting Penrose-St. Francis’ ability to serve the needs of our community in the years to come,” said COO Jameson Smith.
The rest of the tenants will move by Dec. 31.